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VIAGRA [Sildenafil citrate] An Overview
VIAGRA [Sildenafil citrate] is the only approved and effective oral agent for the treatment of erectile dysfunction. Before that a few lines on erectile dysfunction. Erectile dysfunction [Impotence] is a condition in which erection the penis cannot be achieved during sexual intercourse/masturbation. There are many causes for erectile dysfunction. The most common cause of being increasing age. Other conditions can be: - Diabetes Mellitus - Hypertension - Heart Disease - Atherosclerosis - Lower spinal cord injury - Cancer prostate - Psychogenic - Stress Erection is achieved when there is increased blood flow to penis and hence the main organic cause is disturbance of blood flow to and from the penis. Coming back to VIAGRA [Sildenafil citrate], Viagra is a selective and potent inhibitor of cyclic guanosine monophosphate [cGMP] specific phosphodiesterase type 5 inhibitor [PDE5] which is the predominant phosphodiesterase isoform found in the penis. It is administered in doses of 25, 50 and 100 mg, and enhances erection after sexual stimulation. The onset of action is around 60-90 mins. Sildenafil (compound UK-92,480) was synthesized by a group of chemists working at Pfizer's Sandwich, Kent research facility in England. It was initially studied for use in hypertension and angina pectoris. The first clinical trials were conducted in Morriston Hospital in Swansea. Phase I clinical trials under the direction of Ian Osterloh suggested that the drug had little effect on angina, but that it could induce marked penile erections. VIAGRA [Sildenafil citrate] was approved for use in erectile dysfunction by the Food and Drug Administration on March 27, 1998, becoming the first pill approved to treat erectile dysfunction Reduced initial doses should be considered for patients, who are elderly, have renal insufficiency, or are taking medications that inhibit the CYP3A4 metabolic pathway in the liver [e.g., erythromycin, cimetidine, ketoconazole] as they may increase the serum concentration of sildenafil. The drug does not affect ejaculation, orgasm or sexual drive. When sexual stimulation causes local release of NO, inhibition of PDE5 by VIAGRA [Sildenafil citrate] causes increased levels of cGMP in the corpus cavernosum of the penis resulting in smooth muscle relaxation and inflow of blood to the corpus cavernosum. Side Effects: ?? Headaches ?? Facial flushing ?? ringing in ears, or sudden hearing loss ?? Dyspepsia ?? Nasal congestion. ?? Abnormal vision [blue halo effect] ?? Diarrhea ?? Dizziness ?? Rashes Viagra can decrease blood flow to the optic nerve of the eye, causing sudden vision loss:- Special precautions: In patients with ?? Bleeding disorders such as hemophilia ?? Liver disorder ?? Kidney disorder ?? Active peptic ulcerations and ?? Anatomical deformation of the penis, such as peyronie's disease. ?? Retinitis pigmentosa Contraindications: VIAGRA [Sildenafil citrate], is contraindicated in men receiving nitrate therapy for cardiovascular disease, including agents delivered by oral, sublingual, trans-nasal or topical routes. These agents can potentates its hypotensive effect and may result in profound shock. Viagra should be avoided in patients with congestive heart failure and cardiomyopathy because of the risk of vascular collapse.
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Learn More about
Natural Male Enhancements
A lot of guys think erectile dysfunction and are ready to run for the hills. No one wants to be seen as impotent. There is something "un-manly" about not being able to maintain a firm erection long enough to have sex. But really, erectile dysfunction is a lot more common that you might think. And it's nothing to be ashamed of or to necessarily cause any major concern.
Most men will have... 
Like other medication, Viagra is becoming more and more popular in UK. Everyday hundreds of thousands people search over the internet for Viagra in UK and by using it they are getting good results and their personal life is passing good. This magical blue pill has changed thinking of people who felt themselves useless about sexual activities due to erectile dysfunction. Viagra UK is to be...
Most men are extremely bothered by erectile dysfunction. Herbal treatment has been found to be one of the safest and efficacious ways to deal with it. With the number of herbal medicines in the market that promise harder erections and improvement in sexual performance, it can be quite confusing which one really delivers results.
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Sexual Impotence is also defined as erectile dysfunction. Impotence is a common problem that affects many men at least once during life. According to a study conducted in the United States, the incidence of impotence varies with age and increases in proportion of affected men: 7 to 8% for men ages 20 to 39 and 55-60% Men aged over 70 years. The largest increment is seen for men aged 60 to...
Sometimes erectile dysfunction is also referred to as impotence.
Having erectile dysfunction means that you are having problems
achieving and maintaining an erection for sexual intercourse.
If you have such a problem, you should not be ashamed of it
because it is actually quite natural and erectile dysfunction
affects more men than you would expect. However, it is not
commonly discussed...
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